Wild Bill Hickok (Gary Cooper), Calamity Jane (Jean Arthur) and Buffalo Bill (James Ellison) go up against Indians and a gunrunner.
Buffalo Bill and Wild Bill Hickok join forces to establish a mail route that can get mail from St. Joseph, Missouri, to Sacramento, California, in ten days. Along the way they must battle bad weather, hostile Indians and outlaws intent on robbing the mail and shutting down the entire operation.
Calamity Jane tries to help Buffalo Bill Cody and Wild Bill Hickock stop an Indian war.
When the young Texas Ranger, John Reid, is the sole survivor of an ambush arranged by the militaristic outlaw leader, Butch Cavendich, he is rescued by an old childhood Comanche friend, Tonto. When he recovers from his wounds, he dedicates his life to fighting the evil that Cavendich represents. To this end, John Reid becomes the great masked western hero, The Lone Ranger. With the help of Tonto, the pair go to rescue President Grant when Cavendich takes him hostage.
The sheriff of a small town in southwest Texas must keep custody of a murderer whose brother, a powerful rancher, is trying to help him escape. After a friend is killed trying to muster support for him, he and his deputies - a disgraced drunk and a cantankerous old cripple - must find a way to hold out against the rancher's hired guns until the marshal arrives. In the meantime, matters are complicated by the presence of a young gunslinger - and a mysterious beauty who just came in on the last stagecoach.
Lawman Wyatt Earp and outlaw Doc Holliday form an unlikely alliance which culminates in their participation in the legendary Gunfight at the O.K. Corral.
Cole Thornton, a gunfighter for hire, joins forces with an old friend, Sheriff J.P. Hara. Together with an old indian fighter and a gambler, they help a rancher and his family fight a rival rancher that is trying to steal their water.
Four unwitting heroes cross paths on their journey to the sleepy town of Silverado. Little do they know the town where their family and friends reside has been taken over by a corrupt sheriff and a murderous posse. It's up to the sharp-shooting foursome to save the day, but first they have to break each other out of jail, and learn who their real friends are.