When Professor Henry Jones Sr. is invited to give lectures all over the world in May 1908, he takes along his wife and son, and invites his former tutor Miss Helen Seymour to teach Henry Jr. during the trip. Their first stop is Cairo, Egypt. When Junior, who prefers to be called 'Indy' and Miss Seymour visit the pyramids, they are invited by T.E. Lawrence (another former student of hers) to join an archaeological dig. When the mummy disappears and a priceless headpiece is stolen, young Indy gets his first taste of adventure. On their next stop in Tangiers, the family stays with Professor Jones' former class mate Walter Harris. Indy befriends a young slave named Omar who belongs to Emily Keen. The two of them get into trouble when they Indy insists on visiting the market place to see a salted head displayed on a pole. Caught by slave traders, they are end up at an auction from which only Harris can attempt to rescue them.
When Dr. Henry Jones Sr. suddenly goes missing while pursuing the Holy Grail, eminent archaeologist Indiana must team up with Marcus Brody, Sallah and Elsa Schneider to follow in his father's footsteps and stop the Nazis from recovering the power of eternal life.
Set during the Cold War, the Soviets – led by sword-wielding Irina Spalko – are in search of a crystal skull which has supernatural powers related to a mystical Lost City of Gold. After being captured and then escaping from them, Indy is coerced to head to Peru at the behest of a young man whose friend – and Indy's colleague – Professor Oxley has been captured for his knowledge of the skull's whereabouts.
A freak hurricane hits Los Angeles, causing man-eating sharks to be scooped up in tornadoes and flooding the city with shark-infested seawater. Surfer and bar-owner Fin sets out with his friends Baz and Nova to rescue his estranged wife April and teenage daughter Claudia.
Working with a beautiful lady spy, Indiana Jones is assigned to assist the British forces in their attack on the Turkish-occupied town of Beersheba. With a regiment of the Australian Lighthorsemen approaching, Indy must defuse the explosives the Turks have placed throughout the town.
January, 1910. The Jones family attends a meeting of the Theosophy movement in Benares, India. There young Indy befriends a young boy named Jiddu Krishnamurti who is presented by the society to be the next world teacher and possible messiah. Traveling on to China in March, mother Jones takes Miss Seymour and Indy on a sightseeing trip while father meets with Chinese translator Yen Fu. Indy becomes ill during a rain storm and the travelers seek shelter with a poor Chinese family. Dispite the misgivings of his mother, a local doctor is allowed to treat the boy with acupuncture.
In a seemingly perfect community, without war, pain, suffering, differences or choice, a young boy is chosen to learn from an elderly man about the true pain and pleasure of the "real" world.
On safari in British East Africa in September 1910, ten year old Indiana Jones befriends a Massai boy named Meto who helps him in his search for the little seen Fringe-Eared Oryx for former US President Teddy Roosevelt. From there on he and his family and tutor travel to Paris, France where Indy meets a young Norman Rockwell and gets involved in a quarrel between the painters Edgar Degas and Pablo Picasso. The young American boys get a fascinating insight into modern art as Picasso schemes to one up the old master Degas.